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Determining sequencing depth in a single-cell RNA-seq experiment

An underlying question for virtually all single-cell RNA sequencing experiments is how to allocate the limited sequencing budget: deep sequencing of a few cells or shallow sequencing of many cells? Here we present a mathematical framework which reveals that, for estimating many important gene proper...

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Publicat a:Nat Commun
Autors principals: Zhang, Martin Jinye, Ntranos, Vasilis, Tse, David
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005864/
https://ncbi.nlm.nih.gov/pubmed/32034137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14482-y
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