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Determining sequencing depth in a single-cell RNA-seq experiment

An underlying question for virtually all single-cell RNA sequencing experiments is how to allocate the limited sequencing budget: deep sequencing of a few cells or shallow sequencing of many cells? Here we present a mathematical framework which reveals that, for estimating many important gene proper...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Martin Jinye, Ntranos, Vasilis, Tse, David
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005864/
https://ncbi.nlm.nih.gov/pubmed/32034137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14482-y
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