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Determining sequencing depth in a single-cell RNA-seq experiment

An underlying question for virtually all single-cell RNA sequencing experiments is how to allocate the limited sequencing budget: deep sequencing of a few cells or shallow sequencing of many cells? Here we present a mathematical framework which reveals that, for estimating many important gene proper...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Martin Jinye, Ntranos, Vasilis, Tse, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005864/
https://ncbi.nlm.nih.gov/pubmed/32034137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14482-y
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