Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

Lung squamous cell carcinomas (SCCs) are highly aggressive tumors, and there is currently no effective targeted therapy owing to the lack of specific mutation targets. Compared with lung adenocarcinoma (ADCs), lung SCCs reportedly utilized higher levels of glucose metabolism to meet the anabolic and...

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Vydáno v:Front Oncol
Hlavní autoři: Guo, Wenzheng, Kuang, Yanbin, Wu, Jingjing, Wen, Donghua, Zhou, Aiping, Liao, Yueling, Song, Hongyong, Xu, Dongliang, Wang, Tong, Jing, Bo, Li, Kaimi, Hu, Min, Ling, Jing, Wang, Qi, Wu, Wenjuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005048/
https://ncbi.nlm.nih.gov/pubmed/32083006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00052
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