Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

Lung squamous cell carcinomas (SCCs) are highly aggressive tumors, and there is currently no effective targeted therapy owing to the lack of specific mutation targets. Compared with lung adenocarcinoma (ADCs), lung SCCs reportedly utilized higher levels of glucose metabolism to meet the anabolic and...

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Detalles Bibliográficos
Publicado en:Front Oncol
Autores principales: Guo, Wenzheng, Kuang, Yanbin, Wu, Jingjing, Wen, Donghua, Zhou, Aiping, Liao, Yueling, Song, Hongyong, Xu, Dongliang, Wang, Tong, Jing, Bo, Li, Kaimi, Hu, Min, Ling, Jing, Wang, Qi, Wu, Wenjuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005048/
https://ncbi.nlm.nih.gov/pubmed/32083006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00052
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