Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

Lung squamous cell carcinomas (SCCs) are highly aggressive tumors, and there is currently no effective targeted therapy owing to the lack of specific mutation targets. Compared with lung adenocarcinoma (ADCs), lung SCCs reportedly utilized higher levels of glucose metabolism to meet the anabolic and...

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Опубликовано в: :Front Oncol
Главные авторы: Guo, Wenzheng, Kuang, Yanbin, Wu, Jingjing, Wen, Donghua, Zhou, Aiping, Liao, Yueling, Song, Hongyong, Xu, Dongliang, Wang, Tong, Jing, Bo, Li, Kaimi, Hu, Min, Ling, Jing, Wang, Qi, Wu, Wenjuan
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Oncology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005048/
https://ncbi.nlm.nih.gov/pubmed/32083006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00052
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