Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway

Iron dysregulation is associated with several diseases, including lung cancer, but the underlying mechanism is yet unknown. Iron directly binds CDK1, which is upregulated in several cancers, thereby promoting JAK1 phosphorylation and activation of STAT3 signaling to promote colorectal carcinogenesis...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kuang, Yanbin, Guo, Wenzheng, Ling, Jing, Xu, Dongliang, Liao, Yueling, Zhao, Hui, Du, Xiaohui, Wang, Han, Xu, Mingxin, Song, Hongyong, Wang, Tong, Jing, Bo, Li, Kaimi, Hu, Min, Wu, Wenjuan, Deng, Jiong, Wang, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443808/
https://ncbi.nlm.nih.gov/pubmed/30931929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1528-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados