Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway

Iron dysregulation is associated with several diseases, including lung cancer, but the underlying mechanism is yet unknown. Iron directly binds CDK1, which is upregulated in several cancers, thereby promoting JAK1 phosphorylation and activation of STAT3 signaling to promote colorectal carcinogenesis...

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Pubblicato in:Cell Death Dis
Autori principali: Kuang, Yanbin, Guo, Wenzheng, Ling, Jing, Xu, Dongliang, Liao, Yueling, Zhao, Hui, Du, Xiaohui, Wang, Han, Xu, Mingxin, Song, Hongyong, Wang, Tong, Jing, Bo, Li, Kaimi, Hu, Min, Wu, Wenjuan, Deng, Jiong, Wang, Qi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443808/
https://ncbi.nlm.nih.gov/pubmed/30931929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1528-y
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