Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment

Myeloid-derived suppressor cells (MDSC) are present in most cancer patients where they are significant contributors to the immune suppressive tumor microenvironment (TME). The TME is a hostile locale due to deficiencies in oxygen (hypoxia) and nutrients, and the presence of reactive oxygen species (...

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Veröffentlicht in:Cancer Immunol Immunother
Hauptverfasser: Ostrand-Rosenberg, Suzanne, Beury, Daniel W., Parker, Katherine H., Horn, Lucas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2019
Schlagworte:
Focussed Research Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004852/
https://ncbi.nlm.nih.gov/pubmed/31501954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-019-02388-8
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