Discovery of β-Arrestin Biased, Orally Bioavailable and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated in a wide variety of CNS disorders but despite extensive efforts to develop small molecule ligand...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Pinkerton, Anthony B., Peddibhotla, Satyamaheshwar, Yamamoto, Fusayo, Slosky, Lauren M., Bai, Yushi, Maloney, Patrick, Hershberger, Paul, Hedrick, Michael P., Falter, Bekhi, Ardecky, Robert J., Smith, Layton H., Chung, Thomas D. Y., Jackson, Michael R., Caron, Marc G., Barak, Lawrence S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003992/
https://ncbi.nlm.nih.gov/pubmed/31390201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00340
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak