Discovery of β-Arrestin Biased, Orally Bioavailable and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators

Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated in a wide variety of CNS disorders but despite extensive efforts to develop small molecule ligand...

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Vydáno v:J Med Chem
Hlavní autoři: Pinkerton, Anthony B., Peddibhotla, Satyamaheshwar, Yamamoto, Fusayo, Slosky, Lauren M., Bai, Yushi, Maloney, Patrick, Hershberger, Paul, Hedrick, Michael P., Falter, Bekhi, Ardecky, Robert J., Smith, Layton H., Chung, Thomas D. Y., Jackson, Michael R., Caron, Marc G., Barak, Lawrence S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003992/
https://ncbi.nlm.nih.gov/pubmed/31390201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00340
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