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BATCAVE: calling somatic mutations with a tumor- and site-specific prior

Detecting somatic mutations withins tumors is key to understanding treatment resistance, patient prognosis and tumor evolution. Mutations at low allelic frequency, those present in only a small portion of tumor cells, are particularly difficult to detect. Many algorithms have been developed to detec...

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Bibliografske podrobnosti
izdano v:NAR Genom Bioinform
Main Authors: Mannakee, Brian K, Gutenkunst, Ryan N
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003682/
https://ncbi.nlm.nih.gov/pubmed/32051931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nargab/lqaa004
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