Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors

MOTIVATION: Tumor genome sequencing offers great promise for guiding research and therapy, but spurious variant calls can arise from multiple sources. Mouse contamination can generate many spurious calls when sequencing patient-derived xenografts. Paralogous genome sequences can also generate spurio...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioinformatics
Main Authors: Mannakee, Brian K, Balaji, Uthra, Witkiewicz, Agnieszka K, Gutenkunst, Ryan N, Knudsen, Erik S
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946891/
https://ncbi.nlm.nih.gov/pubmed/29325072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty010
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