FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes

BACKGROUND: Mutations in the gene encoding inverted formin-2 (INF2), a member of the formin family of actin regulatory proteins, are among the most common causes of autosomal dominant FSGS. INF2 is regulated by interaction between its N-terminal diaphanous inhibitory domain (DID) and its C-terminal...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Subramanian, Balajikarthick, Chun, Justin, Perez-Gill, Chandra, Yan, Paul, Stillman, Isaac E., Higgs, Henry N., Alper, Seth L., Schlöndorff, Johannes S., Pollak, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003299/
https://ncbi.nlm.nih.gov/pubmed/31924668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019050443
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