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Dysregulated Dynein-Mediated Trafficking of Nephrin Causes INF2-related Podocytopathy

BACKGROUND: FSGS caused by mutations in INF2 is characterized by a podocytopathy with mistrafficked nephrin, an essential component of the slit diaphragm. Because INF2 is a formin-type actin nucleator, research has focused on its actin-regulating function, providing an important but incomplete insig...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Sun, Hua, Perez-Gill, Chandra, Schlöndorff, Johannes S, Subramanian, Balajikarthick, Pollak, Martin R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054882/
https://ncbi.nlm.nih.gov/pubmed/33443052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020081109
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