Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder. It is featured by the progressive accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles. This can eventually lead to a decrease of cholinergic neurons in the basal forebrain. Stem cell transplant...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Zhu, Qing, Zhang, Nianping, Hu, Nan, Jiang, Rongrong, Lu, Huicong, Xuan, Aiguo, Long, Dahong, Chen, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002968/
https://ncbi.nlm.nih.gov/pubmed/31922229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.10918
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