Reorganization of Cholinergic Terminals in the Cerebral Cortex and Hippocampus in Transgenic Mice Carrying Mutated Presenilin-1 and Amyloid Precursor Protein Transgenes

Cholinergic deficits are one of the most consistent neuropathological landmarks in Alzheimer’s disease (AD). We have examined transgenic mouse models (PS1(M146L), APP(K670N,M671L)) and a doubly transgenic line (APP(K670N,M671L) + PS1(M146L)) that overexpress mutated AD-related genes [presenilin-1 (P...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Wong, Tak Pan, Debeir, Thomas, Duff, Karen, Cuello, A. Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1999
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786057/
https://ncbi.nlm.nih.gov/pubmed/10087083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-07-02706.1999
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