Selectively Reduced Expression of Synaptic Plasticity-Related Genes in Amyloid Precursor Protein + Presenilin-1 Transgenic Mice

A critical question in Alzheimer's disease (AD) research is the cause of memory loss that leads to dementia. The amyloid precursor protein + presenilin-1 (APP+PS1) transgenic mouse is a model for amyloid deposition, and like AD, the mice develop memory deficits as amyloid deposits accumulate. W...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Dickey, Chad A., Loring, Jeanne F., Montgomery, Julia, Gordon, Marcia N., Eastman, P. Scott, Morgan, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Development/Plasticity/Repair
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741153/
https://ncbi.nlm.nih.gov/pubmed/12832546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-12-05219.2003
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