Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues

The biological significance of the DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) remains obscure due to its catalytic redundancy with the ubiquitous OGDH-encoded 2-oxoglutarate dehydrogenase (OGDH). In this work, metabolic contributions of OADH and OGDH are discriminated by exposure of cells/tiss...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Artiukhov, Artem V., Grabarska, Aneta, Gumbarewicz, Ewelina, Aleshin, Vasily A., Kähne, Thilo, Obata, Toshihiro, Kazantsev, Alexey V., Lukashev, Nikolay V., Stepulak, Andrzej, Fernie, Alisdair R., Bunik, Victoria I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002488/
https://ncbi.nlm.nih.gov/pubmed/32024885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58701-4
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky