Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays

Cellular NAD(P)H-dependent oxidoreductase activity with artificial dyes (NAD(P)H-OR) is an indicator of viability, as the cellular redox state is important for biosynthesis and antioxidant defense. However, high NAD(P)H due to impaired mitochondrial oxidation, known as reductive stress, should incre...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Aleshin, Vasily A., Artiukhov, Artem V., Oppermann, Henry, Kazantsev, Alexey V., Lukashev, Nikolay V., Bunik, Victoria I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588044/
https://ncbi.nlm.nih.gov/pubmed/26308058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells4030427
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