Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells

The pyruvate dehydrogenase complex (PDHC) and its phosphorylation are considered essential for oncotransformation, but it is unclear whether cancer cells require PDHC to be functional or silenced. We used specific inhibition of PDHC by synthetic structural analogs of pyruvate to resolve this questio...

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Publicat a:Oncotarget
Autors principals: Bunik, Victoria I., Artiukhov, Artem, Kazantsev, Alexey, Goncalves, Renata, Daloso, Danilo, Oppermann, Henry, Kulakovskaya, Elena, Lukashev, Nikolay, Fernie, Alisdair, Brand, Martin, Gaunitz, Frank
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741878/
https://ncbi.nlm.nih.gov/pubmed/26503465
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