Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner

2-Oxoglutarate dehydrogenase (OGDH) of the tricarboxylic acid (TCA) cycle is often implied to be inactive in cancer, but this was not experimentally tested. We addressed the question through specific inhibition of OGDH by succinyl phosphonate (SP). SP action on different cancer cells was investigate...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bunik, Victoria I., Mkrtchyan, Garik, Grabarska, Aneta, Oppermann, Henry, Daloso, Danilo, Araujo, Wagner L., Juszczak, Malgorzata, Rzeski, Wojciech, Bettendorff, Lucien, Fernie, Alisdair R., Meixensberger, Jürgen, Stepulak, Andrzej, Gaunitz, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041988/
https://ncbi.nlm.nih.gov/pubmed/27027236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8387
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