Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner

2-Oxoglutarate dehydrogenase (OGDH) of the tricarboxylic acid (TCA) cycle is often implied to be inactive in cancer, but this was not experimentally tested. We addressed the question through specific inhibition of OGDH by succinyl phosphonate (SP). SP action on different cancer cells was investigate...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Bunik, Victoria I., Mkrtchyan, Garik, Grabarska, Aneta, Oppermann, Henry, Daloso, Danilo, Araujo, Wagner L., Juszczak, Malgorzata, Rzeski, Wojciech, Bettendorff, Lucien, Fernie, Alisdair R., Meixensberger, Jürgen, Stepulak, Andrzej, Gaunitz, Frank
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041988/
https://ncbi.nlm.nih.gov/pubmed/27027236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8387
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