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SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis

BACKGROUND: Cardiac dysfunction, a common complication from severe sepsis, is associated with increased morbidity and mortality. However, the molecular mechanisms of septic cardiac dysfunction are poorly understood. SIRT1, a member of the sirtuin family of NAD+-dependent protein deacetylases, is an...

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Detalhes bibliográficos
Publicado no:Shock
Main Authors: Smith, Lane M., Yoza, Barbara K., Hoth, J. Jason, McCall, Charles E., Vachharajani, Vidula
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002289/
https://ncbi.nlm.nih.gov/pubmed/31393272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001429
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