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SIRT1 Mediates a Primed Response to Immune Challenge after Traumatic Lung Injury

BACKGROUND: Pulmonary contusion (PC) is a common, potentially lethal injury that results in priming for exaggerated inflammatory responses to subsequent immune challenge like infection (2(nd) hit). The molecular mechanism of priming and the 2(nd) hit phenomenon after PC remain obscure. Using a mouse...

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Bibliografische gegevens
Gepubliceerd in:J Trauma Acute Care Surg
Hoofdauteurs: Smith, Lane M., Wells, Jonathan D., Vachharajani, Vidula T., Yoza, Barbara K., McCall, Charles E., Hoth, J. Jason
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410426/
https://ncbi.nlm.nih.gov/pubmed/25909427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000000598
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