Heme oxygenase‐1 deficiency triggers exhaustion of hematopoietic stem cells

While intrinsic changes in aging hematopoietic stem cells (HSCs) are well characterized, it remains unclear how extrinsic factors affect HSC aging. Here, we demonstrate that cells in the niche—endothelial cells (ECs) and CXCL12‐abundant reticular cells (CARs)—highly express the heme‐degrading enzyme...

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Vydáno v:EMBO Rep
Hlavní autoři: Szade, Krzysztof, Zukowska, Monika, Szade, Agata, Nowak, Witold, Skulimowska, Izabella, Ciesla, Maciej, Bukowska‐Strakova, Karolina, Gulati, Gunsagar Singh, Kachamakova‐Trojanowska, Neli, Kusienicka, Anna, Einwallner, Elisa, Kijowski, Jacek, Czauderna, Szymon, Esterbauer, Harald, Benes, Vladimir, L Weissman, Irving, Dulak, Jozef, Jozkowicz, Alicja
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001511/
https://ncbi.nlm.nih.gov/pubmed/31885181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201947895
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