Heme oxygenase‐1 deficiency triggers exhaustion of hematopoietic stem cells

While intrinsic changes in aging hematopoietic stem cells (HSCs) are well characterized, it remains unclear how extrinsic factors affect HSC aging. Here, we demonstrate that cells in the niche—endothelial cells (ECs) and CXCL12‐abundant reticular cells (CARs)—highly express the heme‐degrading enzyme...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Szade, Krzysztof, Zukowska, Monika, Szade, Agata, Nowak, Witold, Skulimowska, Izabella, Ciesla, Maciej, Bukowska‐Strakova, Karolina, Gulati, Gunsagar Singh, Kachamakova‐Trojanowska, Neli, Kusienicka, Anna, Einwallner, Elisa, Kijowski, Jacek, Czauderna, Szymon, Esterbauer, Harald, Benes, Vladimir, L Weissman, Irving, Dulak, Jozef, Jozkowicz, Alicja
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001511/
https://ncbi.nlm.nih.gov/pubmed/31885181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201947895
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