Heme oxygenase‐1 deficiency triggers exhaustion of hematopoietic stem cells

While intrinsic changes in aging hematopoietic stem cells (HSCs) are well characterized, it remains unclear how extrinsic factors affect HSC aging. Here, we demonstrate that cells in the niche—endothelial cells (ECs) and CXCL12‐abundant reticular cells (CARs)—highly express the heme‐degrading enzyme...

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Pubblicato in:EMBO Rep
Autori principali: Szade, Krzysztof, Zukowska, Monika, Szade, Agata, Nowak, Witold, Skulimowska, Izabella, Ciesla, Maciej, Bukowska‐Strakova, Karolina, Gulati, Gunsagar Singh, Kachamakova‐Trojanowska, Neli, Kusienicka, Anna, Einwallner, Elisa, Kijowski, Jacek, Czauderna, Szymon, Esterbauer, Harald, Benes, Vladimir, L Weissman, Irving, Dulak, Jozef, Jozkowicz, Alicja
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001511/
https://ncbi.nlm.nih.gov/pubmed/31885181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201947895
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