Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

Diabetic nephropathy (DN) is the leading cause of end‐stage kidney disease. TGF‐β1/Smad3 signalling plays a major pathological role in DN; however, the contribution of Smad4 has not been examined. Smad4 depletion in the kidney using anti‐Smad4 locked nucleic acid halted progressive podocyte damage a...

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Gepubliceerd in:EMBO Rep
Hoofdauteurs: Li, Jinhua, Sun, Yu Bo Yang, Chen, Weiyi, Fan, Jinjin, Li, Songhui, Qu, Xinli, Chen, Qikang, Chen, Riling, Zhu, Dajian, Zhang, Jinfeng, Wu, Zhuguo, Chi, Honggang, Crawford, Simon, Oorschot, Viola, Puelles, Victor G, Kerr, Peter G, Ren, Yi, Nilsson, Susan K, Christian, Mark, Tang, Huanwen, Chen, Wei, Bertram, John F, Nikolic‐Paterson, David J, Yu, Xueqing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001498/
https://ncbi.nlm.nih.gov/pubmed/31916354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948781
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