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Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

The accumulation of phosphorylated tau protein (pTau) in the entorhinal cortex (EC) is the earliest tau pathology in Alzheimer’s disease (AD). Tau tubulin kinase-1 (TTBK1) is a neuron-specific tau kinase and expressed in the EC and hippocampal regions in both human and mouse brains. Here we report t...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Acta Neuropathol Commun
Asıl Yazarlar: Ikezu, Seiko, Ingraham Dixie, Kaitlin L., Koro, Lacin, Watanabe, Takashi, Kaibuchi, Kozo, Ikezu, Tsuneya
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001309/
https://ncbi.nlm.nih.gov/pubmed/32019603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-0890-4
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