Accelerated Neurodegeneration and Neuroinflammation in Transgenic Mice Expressing P301L Tau Mutant and Tau-Tubulin Kinase 1

Tau-tubulin kinase-1 (TTBK1) is a central nervous system (CNS)–specific protein kinase implicated in the pathological phosphorylation of tau. TTBK1-transgenic mice show enhanced neuroinflammation in the CNS. Double-transgenic mice expressing TTBK1 and frontotemporal dementia with parkinsonism-17–lin...

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Bibliografiske detaljer
Main Authors: Asai, Hirohide, Ikezu, Seiko, Woodbury, Maya E., Yonemoto, Grant M.S., Cui, Libin, Ikezu, Tsuneya
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2014
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936332/
https://ncbi.nlm.nih.gov/pubmed/24418258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.11.026
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