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Accelerated Neurodegeneration and Neuroinflammation in Transgenic Mice Expressing P301L Tau Mutant and Tau-Tubulin Kinase 1
Tau-tubulin kinase-1 (TTBK1) is a central nervous system (CNS)–specific protein kinase implicated in the pathological phosphorylation of tau. TTBK1-transgenic mice show enhanced neuroinflammation in the CNS. Double-transgenic mice expressing TTBK1 and frontotemporal dementia with parkinsonism-17–lin...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Investigative Pathology
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936332/ https://ncbi.nlm.nih.gov/pubmed/24418258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.11.026 |
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