Accelerated Neurodegeneration and Neuroinflammation in Transgenic Mice Expressing P301L Tau Mutant and Tau-Tubulin Kinase 1

Tau-tubulin kinase-1 (TTBK1) is a central nervous system (CNS)–specific protein kinase implicated in the pathological phosphorylation of tau. TTBK1-transgenic mice show enhanced neuroinflammation in the CNS. Double-transgenic mice expressing TTBK1 and frontotemporal dementia with parkinsonism-17–lin...

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Bibliografiska uppgifter
Huvudupphovsmän: Asai, Hirohide, Ikezu, Seiko, Woodbury, Maya E., Yonemoto, Grant M.S., Cui, Libin, Ikezu, Tsuneya
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2014
Ämnen:
Regular Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936332/
https://ncbi.nlm.nih.gov/pubmed/24418258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.11.026
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