Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

The identification of mutations in the Tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has made it possible to express human tau protein with pathogenic mutations in transgenic animals. Here we report on the production and characterization of a line of mice tra...

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Publicado no:J Neurosci
Main Authors: Allen, Bridget, Ingram, Esther, Takao, Masaki, Smith, Michael J., Jakes, Ross, Virdee, Kanwar, Yoshida, Hirotaka, Holzer, Max, Craxton, Molly, Emson, Piers C., Atzori, Cristiana, Migheli, Antonio, Crowther, R. Anthony, Ghetti, Bernardino, Spillantini, Maria Grazia, Goedert, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758022/
https://ncbi.nlm.nih.gov/pubmed/12417659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-21-09340.2002
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