Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

The identification of mutations in the Tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has made it possible to express human tau protein with pathogenic mutations in transgenic animals. Here we report on the production and characterization of a line of mice tra...

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Vydáno v:J Neurosci
Hlavní autoři: Allen, Bridget, Ingram, Esther, Takao, Masaki, Smith, Michael J., Jakes, Ross, Virdee, Kanwar, Yoshida, Hirotaka, Holzer, Max, Craxton, Molly, Emson, Piers C., Atzori, Cristiana, Migheli, Antonio, Crowther, R. Anthony, Ghetti, Bernardino, Spillantini, Maria Grazia, Goedert, Michel
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758022/
https://ncbi.nlm.nih.gov/pubmed/12417659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-21-09340.2002
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