AAV1.SERCA2a Gene Therapy Reverses Pulmonary Fibrosis by Blocking the STAT3/FOXM1 Pathway and Promoting the SNON/SKI Axis

Inhibition of pulmonary fibrosis (PF) by restoring sarco/endoplasmic reticulum calcium ATPase 2a isoform (SERCA2a) expression using targeted gene therapy may be a potentially powerful new treatment approach for PF. Here, we found that SERCA2a expression was significantly decreased in lung samples fr...

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Publicat a:Mol Ther
Autors principals: Bisserier, Malik, Milara, Javier, Abdeldjebbar, Yassine, Gubara, Sarah, Jones, Carly, Bueno-Beti, Carlos, Chepurko, Elena, Kohlbrenner, Erik, Katz, Michael G., Tarzami, Sima, Cortijo, Julio, Leopold, Jane, Hajjar, Roger J., Sassi, Yassine, Hadri, Lahouaria
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001085/
https://ncbi.nlm.nih.gov/pubmed/31879190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.027
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