A novel secreted-cAMP pathway inhibits pulmonary hypertension via a feed-forward mechanism

AIMS: Cyclic adenosine monophosphate (cAMP) is the predominant intracellular second messenger that transduces signals from Gs-coupled receptors. Intriguingly, there is evidence from various cell types that an extracellular cAMP pathway is active in the extracellular space. Herein, we investigated th...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Jones, Carly, Bisserier, Malik, Bueno-Beti, Carlos, Bonnet, Guillaume, Neves-Zaph, Susana, Lee, Sang-Yong, Milara, Javier, Dorfmüller, Peter, Humbert, Marc, Leopold, Jane A, Hadri, Lahouaria, Hajjar, Roger J, Sassi, Yassine
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314640/
https://ncbi.nlm.nih.gov/pubmed/31529026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvz244
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