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Regulation of the Methylation and Expression levels of the BMPR2 gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension

BACKGROUND-: Epigenetic mechanisms are critical in the pathogenesis of pulmonary arterial hypertension (PAH). Previous studies have suggested that hypermethylation of the Bone Morphogenetic Protein Receptor Type 2 (BMPR2) promoter is associated with BMPR2 downregulation and progression of PAH. Here,...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Bisserier, Malik, Mathiyalagan, Prabhu, Zhang, Shihong, Elmastour, Firas, Dorfmüller, Peter, Humbert, Marc, David, Gregory, Tarzami, Sima, Weber, Thomas, Perros, Frederic, Sassi, Yassine, Sahoo, Susmita, Hadri, Lahouaria
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8293289/
https://ncbi.nlm.nih.gov/pubmed/34078089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.047978
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