Regulation of the Methylation and Expression levels of the BMPR2 gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension

BACKGROUND-: Epigenetic mechanisms are critical in the pathogenesis of pulmonary arterial hypertension (PAH). Previous studies have suggested that hypermethylation of the Bone Morphogenetic Protein Receptor Type 2 (BMPR2) promoter is associated with BMPR2 downregulation and progression of PAH. Here,...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Circulation
Main Authors: Bisserier, Malik, Mathiyalagan, Prabhu, Zhang, Shihong, Elmastour, Firas, Dorfmüller, Peter, Humbert, Marc, David, Gregory, Tarzami, Sima, Weber, Thomas, Perros, Frederic, Sassi, Yassine, Sahoo, Susmita, Hadri, Lahouaria
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8293289/
https://ncbi.nlm.nih.gov/pubmed/34078089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.047978
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker