TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1(−/−)) mice and determines the major downstream mediator of Bmi-1 and crosstalk between p16(INK4a) and reactive oxygen species that regulates SAPF, phenotypes were...

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Pubblicato in:Exp Mol Med
Autori principali: Chen, Haiyun, Chen, Hongjie, Liang, Jialong, Gu, Xin, Zhou, Jiawen, Xie, Chunfeng, Lv, Xianhui, Wang, Rong, Li, Qing, Mao, Zhiyuan, Sun, Haijian, Zuo, Guoping, Miao, Dengshun, Jin, Jianliang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000795/
https://ncbi.nlm.nih.gov/pubmed/31959867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0371-7
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