Bmi-1 Absence Causes Premature Brain Degeneration

Bmi-1, a polycomb transcriptional repressor, is implicated in cell cycle regulation and cell senescence. Its absence results in generalized astrogliosis and epilepsy during the postnatal development, but the underlying mechanisms are poorly understood. Here, we demonstrate the occurrence of oxidativ...

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Библиографические подробности
Главные авторы: Cao, Guangliang, Gu, Minxia, Zhu, Min, Gao, Junying, Yin, Ying, Marshall, Charles, Xiao, Ming, Ding, Jiong, Miao, Dengshun
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282795/
https://ncbi.nlm.nih.gov/pubmed/22363787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032015
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