Bmi-1 Absence Causes Premature Brain Degeneration

Bmi-1, a polycomb transcriptional repressor, is implicated in cell cycle regulation and cell senescence. Its absence results in generalized astrogliosis and epilepsy during the postnatal development, but the underlying mechanisms are poorly understood. Here, we demonstrate the occurrence of oxidativ...

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Bibliographic Details
Main Authors: Cao, Guangliang, Gu, Minxia, Zhu, Min, Gao, Junying, Yin, Ying, Marshall, Charles, Xiao, Ming, Ding, Jiong, Miao, Dengshun
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282795/
https://ncbi.nlm.nih.gov/pubmed/22363787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032015
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