P16(INK4a) Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency

To determine whether p16 (INK4a) deletion ameliorated renal tubulointerstitial injury by inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi-1 (−/−)) mice, renal phenotypes were compared among 5-week-old Bmi-1 and p16 (INK4a) double-knockout, and Bmi-1 (−/−) and wil...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Jin, Jianliang, Tao, Jianguo, Gu, Xin, Yu, Zhenzhen, Wang, Rong, Zuo, Guoping, Li, Qing, Lv, Xianhui, Miao, Dengshun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548892/
https://ncbi.nlm.nih.gov/pubmed/28790310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06868-8
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