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TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency
To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1(−/−)) mice and determines the major downstream mediator of Bmi-1 and crosstalk between p16(INK4a) and reactive oxygen species that regulates SAPF, phenotypes were...
Gespeichert in:
| Veröffentlicht in: | Exp Mol Med |
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| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7000795/ https://ncbi.nlm.nih.gov/pubmed/31959867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0371-7 |
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