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Bmi-1 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance
To determine whether Bmi-1 deficiency could lead to renal tubulointerstitial injury by mitochondrial dysfunction and increased oxidative stress in the kidney, 3-week-old Bmi-1(-/-) mice were treated with the antioxidant N-acetylcysteine (NAC, 1 mg mL(−1)) in their drinking water, or pyrro-quinoline...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331754/ https://ncbi.nlm.nih.gov/pubmed/24915841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12236 |
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