Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice

Cerebral dopamine neurotrophic factor (CDNF) is neuroprotective for nigrostriatal dopamine neurons and restores dopaminergic function in animal models of Parkinson’s disease (PD). To understand the role of CDNF in mammals, we generated CDNF knockout mice (Cdnf(−/−)), which are viable, fertile, and h...

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Udgivet i:Neurobiol Dis
Main Authors: Lindahl, Maria, Chalazonitis, Alcmène, Palm, Erik, Pakarinen, Emmi, Danilova, Tatiana, Pham, Tuan D., Setlik, Wanda, Rao, Meenakshi, Võikar, Vootele, Huotari, Jatta, Kopra, Jaakko, Andressoo, Jaan-Olle, Piepponen, Petteri T., Airavaara, Mikko, Panhelainen, Anne, Gershon, Michael D., Saarma, Mart
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000201/
https://ncbi.nlm.nih.gov/pubmed/31783118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104696
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