Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice

Glial cell line-derived neurotrophic factor (GDNF) supports function and survival of dopamine neurons that degenerate in Parkinson’s disease (PD). Ectopic delivery of GDNF in clinical trials to treat PD is safe but lacks significant therapeutic effect. In pre-clinical models, ectopic GDNF is effecti...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Mol Ther Methods Clin Dev
Autors principals: Turconi, Giorgio, Kopra, Jaakko, Võikar, Vootele, Kulesskaya, Natalia, Vilenius, Carolina, Piepponen, T. Petteri, Andressoo, Jaan-Olle
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191127/
https://ncbi.nlm.nih.gov/pubmed/32368564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.04.003
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars