Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice

Glial cell line-derived neurotrophic factor (GDNF) supports function and survival of dopamine neurons that degenerate in Parkinson’s disease (PD). Ectopic delivery of GDNF in clinical trials to treat PD is safe but lacks significant therapeutic effect. In pre-clinical models, ectopic GDNF is effecti...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther Methods Clin Dev
Auteurs principaux: Turconi, Giorgio, Kopra, Jaakko, Võikar, Vootele, Kulesskaya, Natalia, Vilenius, Carolina, Piepponen, T. Petteri, Andressoo, Jaan-Olle
Format: Artigo
Langue:Inglês
Publié: American Society of Gene & Cell Therapy 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191127/
https://ncbi.nlm.nih.gov/pubmed/32368564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.04.003
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