GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson’s disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has been attempted for Parkinson’s disease treatment...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Kumar, Anmol, Kopra, Jaakko, Varendi, Kärt, Porokuokka, Lauriina L., Panhelainen, Anne, Kuure, Satu, Marshall, Pepin, Karalija, Nina, Härma, Mari-Anne, Vilenius, Carolina, Lilleväli, Kersti, Tekko, Triin, Mijatovic, Jelena, Pulkkinen, Nita, Jakobson, Madis, Jakobson, Maili, Ola, Roxana, Palm, Erik, Lindahl, Maria, Strömberg, Ingrid, Võikar, Vootele, Piepponen, T. Petteri, Saarma, Mart, Andressoo, Jaan-Olle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682981/
https://ncbi.nlm.nih.gov/pubmed/26681446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005710
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