GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson’s disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has been attempted for Parkinson’s disease treatment...

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發表在:PLoS Genet
Main Authors: Kumar, Anmol, Kopra, Jaakko, Varendi, Kärt, Porokuokka, Lauriina L., Panhelainen, Anne, Kuure, Satu, Marshall, Pepin, Karalija, Nina, Härma, Mari-Anne, Vilenius, Carolina, Lilleväli, Kersti, Tekko, Triin, Mijatovic, Jelena, Pulkkinen, Nita, Jakobson, Madis, Jakobson, Maili, Ola, Roxana, Palm, Erik, Lindahl, Maria, Strömberg, Ingrid, Võikar, Vootele, Piepponen, T. Petteri, Saarma, Mart, Andressoo, Jaan-Olle
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682981/
https://ncbi.nlm.nih.gov/pubmed/26681446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005710
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