GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson’s disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has been attempted for Parkinson’s disease treatment...

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Published in:PLoS Genet
Main Authors: Kumar, Anmol, Kopra, Jaakko, Varendi, Kärt, Porokuokka, Lauriina L., Panhelainen, Anne, Kuure, Satu, Marshall, Pepin, Karalija, Nina, Härma, Mari-Anne, Vilenius, Carolina, Lilleväli, Kersti, Tekko, Triin, Mijatovic, Jelena, Pulkkinen, Nita, Jakobson, Madis, Jakobson, Maili, Ola, Roxana, Palm, Erik, Lindahl, Maria, Strömberg, Ingrid, Võikar, Vootele, Piepponen, T. Petteri, Saarma, Mart, Andressoo, Jaan-Olle
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682981/
https://ncbi.nlm.nih.gov/pubmed/26681446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005710
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