Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment

The immune checkpoint blockade (ICB) immunotherapy has prolonged overall survival for cancer patients but the response rates are low. The resistance to ICB is likely due to compensatory upregulation of additional immune inhibitory molecules. In this study, we first systematically examined Tim-3 expr...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Yang, Min, Du, Wenwen, Yi, Lixian, Wu, Shaoxian, He, Chunyan, Zhai, Wensi, Yue, Cuihua, Sun, Runzi, Menk, Ashley V., Delgoffe, Greg M., Jiang, Jingting, Lu, Binfeng
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999836/
https://ncbi.nlm.nih.gov/pubmed/32076578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1708064
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