Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment

The immune checkpoint blockade (ICB) immunotherapy has prolonged overall survival for cancer patients but the response rates are low. The resistance to ICB is likely due to compensatory upregulation of additional immune inhibitory molecules. In this study, we first systematically examined Tim-3 expr...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Yang, Min, Du, Wenwen, Yi, Lixian, Wu, Shaoxian, He, Chunyan, Zhai, Wensi, Yue, Cuihua, Sun, Runzi, Menk, Ashley V., Delgoffe, Greg M., Jiang, Jingting, Lu, Binfeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999836/
https://ncbi.nlm.nih.gov/pubmed/32076578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1708064
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