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Elevated pCO(2) affects the lactate metabolic shift in CHO cell culture processes

The shift from lactate production to consumption in CHO cell metabolism is a key event during cell culture cultivations and is connected to increased culture longevity and final product titers. However, the mechanisms controlling this metabolic shift are not yet fully understood. Variations in lacta...

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Detalhes bibliográficos
Publicado no:Eng Life Sci
Main Authors: Brunner, Matthias, Doppler, Philipp, Klein, Tobias, Herwig, Christoph, Fricke, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999464/
https://ncbi.nlm.nih.gov/pubmed/32624899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elsc.201700131
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