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Media photo‐degradation in pharmaceutical biotechnology – impact of ambient light on media quality, cell physiology, and IgG production in CHO cultures

BACKGROUND: Many vital components in bioprocess media are prone to photo‐conversion or photo‐degradation upon exposure to ambient light, with severe negative consequences for biomass yield and overall productivity. However, there is only limited awareness of light irradiation as a potential risk fac...

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Detalhes bibliográficos
Publicado no:J Chem Technol Biotechnol
Main Authors: Neutsch, Lukas, Kroll, Paul, Brunner, Matthias, Pansy, Alexander, Kovar, Michael, Herwig, Christoph, Klein, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055871/
https://ncbi.nlm.nih.gov/pubmed/30069078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jctb.5643
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