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Media photo‐degradation in pharmaceutical biotechnology – impact of ambient light on media quality, cell physiology, and IgG production in CHO cultures

BACKGROUND: Many vital components in bioprocess media are prone to photo‐conversion or photo‐degradation upon exposure to ambient light, with severe negative consequences for biomass yield and overall productivity. However, there is only limited awareness of light irradiation as a potential risk fac...

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Dettagli Bibliografici
Pubblicato in:J Chem Technol Biotechnol
Autori principali: Neutsch, Lukas, Kroll, Paul, Brunner, Matthias, Pansy, Alexander, Kovar, Michael, Herwig, Christoph, Klein, Tobias
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055871/
https://ncbi.nlm.nih.gov/pubmed/30069078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jctb.5643
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