Targeting claudin‐overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin

Clostridium perfringens enterotoxin (CPE) can be used to eliminate carcinoma cells that overexpress on their cell surface CPE receptors – a subset of claudins (e.g., Cldn3 and Cldn4). However, CPE cannot target tumors expressing solely CPE‐insensitive claudins (such as Cldn1 and Cldn5). To overcome...

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Publicat a:Mol Oncol
Autors principals: Piontek, Anna, Eichner, Miriam, Zwanziger, Denise, Beier, Laura‐Sophie, Protze, Jonas, Walther, Wolfgang, Theurer, Sarah, Schmid, Kurt Werner, Führer‐Sakel, Dagmar, Piontek, Jörg, Krause, Gerd
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6998413/
https://ncbi.nlm.nih.gov/pubmed/31825142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12615
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