Molecular Determinants of the Interaction between Clostridium perfringens Enterotoxin Fragments and Claudin-3

Clostridium perfringens enterotoxin (CPE) binds to the extracellular loop 2 of a subset of claudins, e.g. claudin-3. Here, the molecular mechanism of the CPE-claudin interaction was analyzed. Using peptide arrays, recombinant CPE-(116–319) bound to loop 2 peptides of mouse claudin-3, -6, -7, -9, and...

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Autori principali: Winkler, Lars, Gehring, Claudia, Wenzel, Ariane, Müller, Sebastian L., Piehl, Christian, Krause, Gerd, Blasig, Ingolf E., Piontek, Jörg
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707212/
https://ncbi.nlm.nih.gov/pubmed/19429681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008623
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